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Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cell-enriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein—Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup.
Present address: Division of Medical Virology, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia.
Received 29 June 1992;
accepted 5 August 1992.
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E. Flano, I.-J. Kim, J. Moore, D. L. Woodland, and M. A. Blackman Differential {gamma}-Herpesvirus Distribution in Distinct Anatomical Locations and Cell Subsets During Persistent Infection in Mice J. Immunol., April 1, 2003; 170(7): 3828 - 3834. [Abstract] [Full Text] [PDF]
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S. F. Elsawa, W. Taylor, C. C. Petty, I. Marriott, J. V. Weinstock, and K. L. Bost Reduced CTL Response and Increased Viral Burden in Substance P Receptor-Deficient Mice Infected with Murine {gamma}-Herpesvirus 68 J. Immunol., March 1, 2003; 170(5): 2605 - 2612. [Abstract] [Full Text] [PDF]
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H. M. Coleman, B. d. Lima, V. Morton, and P. G. Stevenson Murine Gammaherpesvirus 68 Lacking Thymidine Kinase Shows Severe Attenuation of Lytic Cycle Replication In Vivo but Still Establishes Latency J. Virol., February 15, 2003; 77(4): 2410 - 2417. [Abstract] [Full Text] [PDF]
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K. Blasdell, C. McCracken, A. Morris, A. A. Nash, M. Begon, M. Bennett, and J. P. Stewart The wood mouse is a natural host for Murid herpesvirus 4 J. Gen. Virol., January 1, 2003; 84(1): 111 - 113. [Abstract] [Full Text] [PDF]
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B. J. Lee, U. H. Koszinowski, S. R. Sarawar, and H. Adler A Gammaherpesvirus G Protein-Coupled Receptor Homologue Is Required for Increased Viral Replication in Response to Chemokines and Efficient Reactivation from Latency J. Immunol., January 1, 2003; 170(1): 243 - 251. [Abstract] [Full Text] [PDF]
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 E. Flano, I.-J. Kim, D. L. Woodland, and M. A. Blackman {gamma}-Herpesvirus Latency Is Preferentially Maintained in Splenic Germinal Center and Memory B Cells J. Exp. Med., November 18, 2002; 196(10): 1363 - 1372. [Abstract] [Full Text] [PDF]
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 S.S. Lok, Y. Haider, D. Howell, J.P. Stewart, P.S. Hasleton, and J.J. Egan Murine gammaherpes virus as a cofactor in the development of pulmonary fibrosis in bleomycin resistant mice Eur. Respir. J., November 1, 2002; 20(5): 1228 - 1232. [Abstract] [Full Text] [PDF]
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S. Gangappa, S. B. Kapadia, S. H. Speck, and H. W. Virgin IV Antibody to a Lytic Cycle Viral Protein Decreases Gammaherpesvirus Latency in B-Cell-Deficient Mice J. Virol., October 17, 2002; 76(22): 11460 - 11468. [Abstract] [Full Text] [PDF]
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J. B. Weinberg, M. L. Lutzke, S. Efstathiou, S. L. Kunkel, and R. Rochford Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection J. Virol., September 11, 2002; 76(20): 10518 - 10523. [Abstract] [Full Text] [PDF]
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 B. T. Seet and G. McFadden Viral chemokine-binding proteins J. Leukoc. Biol., July 1, 2002; 72(1): 24 - 34. [Abstract] [Full Text] [PDF]
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S. A. Tibbetts, L. F. van Dyk, S. H. Speck, and H. W. Virgin IV Immune Control of the Number and Reactivation Phenotype of Cells Latently Infected with a Gammaherpesvirus J. Virol., June 14, 2002; 76(14): 7125 - 7132. [Abstract] [Full Text] [PDF]
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E. T. Clambey, H. W. Virgin IV, and S. H. Speck Characterization of a Spontaneous 9.5-Kilobase-Deletion Mutant of Murine Gammaherpesvirus 68 Reveals Tissue-Specific Genetic Requirements for Latency J. Virol., June 5, 2002; 76(13): 6532 - 6544. [Abstract] [Full Text] [PDF]
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I.-J. Kim, E. Flano, D. L. Woodland, and M. A. Blackman Antibody-Mediated Control of Persistent {gamma}-Herpesvirus Infection J. Immunol., April 15, 2002; 168(8): 3958 - 3964. [Abstract] [Full Text] [PDF]
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H. Liu, S. Andreansky, G. Diaz, T. Hogg, and P. C. Doherty Reduced Functional Capacity of CD8+ T Cells Expanded by Post-Exposure Vaccination of {gamma}-Herpesvirus-Infected CD4-Deficient Mice J. Immunol., April 1, 2002; 168(7): 3477 - 3483. [Abstract] [Full Text] [PDF]
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M. A. Jacoby, H. W. Virgin IV, and S. H. Speck Disruption of the M2 Gene of Murine Gammaherpesvirus 68 Alters Splenic Latency following Intranasal, but Not Intraperitoneal, Inoculation J. Virol., February 15, 2002; 76(4): 1790 - 1801. [Abstract] [Full Text] [PDF]
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C. M. Payne, C. J. Heggie, D. G. Brownstein, J. P. Stewart, and J. P. Quinn Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection J. Virol., November 1, 2001; 75(21): 10467 - 10471. [Abstract] [Full Text] [PDF]
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E. Flano, D. L. Woodland, M. A. Blackman, and P. C. Doherty Analysis of Virus-Specific CD4+ T Cells during Long-Term Gammaherpesvirus Infection J. Virol., August 15, 2001; 75(16): 7744 - 7748. [Abstract] [Full Text] [PDF]
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A. Bridgeman, P. G. Stevenson, J. P. Simas, and S. Efstathiou A Secreted Chemokine Binding Protein Encoded by Murine Gammaherpesvirus-68 Is Necessary for the Establishment of a Normal Latent Load J. Exp. Med., August 6, 2001; 194(3): 301 - 312. [Abstract] [Full Text] [PDF]
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D. J. Topham, R. C. Cardin, J. P. Christensen, J. W. Brooks, G. T. Belz, and P. C. Doherty Perforin and Fas in murine gammaherpesvirus-specific CD8+ T cell control and morbidity J. Gen. Virol., August 1, 2001; 82(8): 1971 - 1981. [Abstract] [Full Text] [PDF]
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H. Adler, M. Messerle, and U. H. Koszinowski Virus Reconstituted from Infectious Bacterial Artificial Chromosome (BAC)-Cloned Murine Gammaherpesvirus 68 Acquires Wild-Type Properties In Vivo Only after Excision of BAC Vector Sequences J. Virol., June 15, 2001; 75(12): 5692 - 5696. [Abstract] [Full Text]
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R. Rochford, M. L. Lutzke, R. S. Alfinito, A. Clavo, and R. D. Cardin Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice J. Virol., June 1, 2001; 75(11): 4955 - 4963. [Abstract] [Full Text]
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A. I. Macrae, B. M. Dutia, S. Milligan, D. G. Brownstein, D. J. Allen, J. Mistrikova, A. J. Davison, A. A. Nash, and J. P. Stewart Analysis of a Novel Strain of Murine Gammaherpesvirus Reveals a Genomic Locus Important for Acute Pathogenesis J. Virol., June 1, 2001; 75(11): 5315 - 5327. [Abstract] [Full Text]
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 B. Ebrahimi, B. M. Dutia, D. G. Brownstein, and A. A. Nash Murine Gammaherpesvirus-68 Infection Causes Multi-Organ Fibrosis and Alters Leukocyte Trafficking in Interferon-{{gamma}} Receptor Knockout Mice Am. J. Pathol., June 1, 2001; 158(6): 2117 - 2125. [Abstract] [Full Text] [PDF]
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M. N. Wakeling, D. J. Roy, A. A. Nash, and J. P. Stewart Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor J. Gen. Virol., May 1, 2001; 82(5): 1187 - 1197. [Abstract] [Full Text]
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 G. Donofrio, C. F. Flammini, F. Scatozza, and S. Cavirani Detection of Bovine Herpesvirus 4 (BoHV-4) DNA in the Cell Fraction of Milk of Dairy Cattle with History of BoHV-4 Infection J. Clin. Microbiol., December 1, 2000; 38(12): 4668 - 4671. [Abstract] [Full Text]
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L. A. Terry, J. P. Stewart, A. A. Nash, and J. K. Fazakerley Murine gammaherpesvirus-68 infection of and persistence in the central nervous system J. Gen. Virol., November 1, 2000; 81(11): 2635 - 2643. [Abstract] [Full Text]
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E. J. Usherwood, D. J. Roy, K. Ward, S. L. Surman, B. M. Dutia, M. A. Blackman, J. P. Stewart, and D. L. Woodland Control of Gammaherpesvirus Latency by Latent Antigen-Specific Cd8+ T Cells J. Exp. Med., October 2, 2000; 192(7): 943 - 952. [Abstract] [Full Text] [PDF]
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V. van Berkel, J. Barrett, H. L. Tiffany, D. H. Fremont, P. M. Murphy, G. McFadden, S. H. Speck, and H. W. Virgin IV Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action J. Virol., August 1, 2000; 74(15): 6741 - 6747. [Abstract] [Full Text]
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A. T. Hoge, S. B. Hendrickson, and W. H. Burns Murine Gammaherpesvirus 68 Cyclin D Homologue Is Required for Efficient Reactivation from Latency J. Virol., August 1, 2000; 74(15): 7016 - 7023. [Abstract] [Full Text]
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