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Supplementary Data

Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells, by R. Kumar, D. McLain, R. Young and G. A. Carlson

Journal of General Virology vol. 89, part 6, pp. 1525–1532

Supplementary Fig. S1. PrPC concentrations increase in proportion to 8-Br-cAMP-induced expression of ABCA1.

Supplementary Fig. S2. PrPSc concentrations increase in proportion to 8-Br-cAMP-induced expression of ABCA1.

Supplementary Fig. S3. Levels of PrPC are reduced in proportion to ABCA1 knockdown by RNAi.

Supplementary Fig. S4. Levels of PrPSc are reduced in proportion to ABCA1 knockdown by RNAi.

Supplementary Fig. S5. ABCA1 knockdown by RNAi reduces PrPSc levels.

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