HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Papers in Press[PDF]) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Ming, P. Articles by Yang, X. PubMed PubMed Citation Articles by Ming, P. Articles by Yang, X. Agricola Articles by Ming, P. Articles by Yang, X.

A history estimate and evolutionary analysis of rabies virus variants in China

¹ Wuhan Institute of Biological Products;
² Wuhan Institute of Virology, Chinese Academy of Sciences;
³ National Institute for Viral Disease Control and Prevention, China CDC

⁴ E-mail: pgming2002{at}sina.com

To investigate the evolutionary dynamics of RABV in China, we collected and sequenced 55 isolates sampled from 14 provinces of China over the last 40 years and performed a coalescent-based analysis of the G gene. This revealed that RABV currently circulating in China comprised three main groups. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current RABV Chinese strains to be 1412 (with a 95% confidence interval of 1006-1736). The estimated mean substitution rate for the G gene sequences (3.961x10-4 substitutions per site, per year) was in accordance with previous reports for RABV.

Received 7 September 2009; accepted 2 November 2009.