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Originally published as JGV in Press, 10.1099/vir.0.013615-0 on July 15, 2009 J Gen Virol 90 (2009), 2638-2643; DOI 10.1099/vir.0.013615-0

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Short Communication

Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region

M. S. Gomes-Gouvêa1,2, M. C. P. Soares2, G. Bensabath2, I. M. V. G. de Carvalho-Mello1,3, E. M. F. Brito2, O. S. C. Souza2, A. T. L. Queiroz4, F. J. Carrilho1 and J. R. R. Pinho1

1 Laboratory of Tropical Hepatology and Gastroenterology, Tropical Medicine Institute, Department of Gastroenterology, University of São Paulo Medical School, Av. Dr Enéas Carvalho de Aguiar 500, São Paulo, SP 05403-000, Brazil
2 Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil
3 Laboratório de Imunologia Viral, Instituto Butantan, Avenida Vital Brasil 1500, São Paulo, SP 05503-900, Brazil
4 Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, São Paulo, SP 05508-900, Brazil

Correspondence
M. S. Gomes-Gouvêa
gomesmic{at}yahoo.com.br

The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978–1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4 % of cases, respectively. These results confirm the predominance of HDV-3 in South America and its association with the severe form of hepatitis, and the finding of the co-infection of HDV-3 with different genotypes of HBV suggests that the association between HDV-3 and HBV-F is not necessarily causally related to a more severe clinical course of infection.

The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are FJ010634 [GenBank] –FJ010647 [GenBank] (HDV) and FJ010648 [GenBank] –FJ010661 [GenBank] (HBV).

A supplementary table and two supplementary figures are available with the online version of this paper.






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