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Supragenotypic groups of the hepatitis B virus genome

Aileen C. Gonzales

Division of Viral Hepatitis, MS-A33, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30329-4018, USA

Correspondence
Michael A. Purdy
mup3{at}cdc.gov

Phylogenetic relationships among hepatitis B virus (HBV) genotypes were investigated using different regions across the genome. The phylogenetic analysis in conjunction with graphical examination of phylogenetic distance matrices and distance frequency distribution plotting suggest the clustering of HBV genotypes into three higher-order hierarchical groups: group I, comprising genotypes A–E and G; group II, comprising genotypes F and H; and a hypothetical group III. Present-day genotype G is postulated to be a recombinant with the non-polymerase region of group III virus and the polymerase gene of an ancestral virus belonging to group I.

Present address: Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109, USA.

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