HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morinaga, N. Articles by Kuwata, T. Search for Related Content PubMed PubMed Citation Articles by Morinaga, N. Articles by Kuwata, T. Agricola Articles by Morinaga, N. Articles by Kuwata, T.

Cross-resistance to Human Interferon- of Human Interferon--resistant F-IF^r Cells

¹ Department of Microbiology, School of Medicine, Chiba University, 1-8-1 Inohana, Chiba 280, Japan
and² The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113, Japan

F-IF^r cells, which are more resistant to the anticellular and antiviral action of human and interferons (IFN- and IFN-) than the parental RSa cells, were also found to be more resistant to both the anticellular and antiviral effect of IFN-. A high level of 2–5A synthetase was induced by treatment with IFN- or -, but induction of 2–5A synthetase was not detected after IFN- treatment of the cells. F-IF^r cells had less than half the number of specific binding sites for IFN- than the parental RSa cells.

Keywords: interferon, human , and , cross-resistance

Received 9 September 1983; accepted 8 March 1984.