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J Gen Virol 64 (1983), 1543-1555; DOI 10.1099/0022-1317-64-7-1543
© 1983 Society for General Microbiology
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Antiviral Activities Directed Against Wild-type and Interferon-sensitive Mengovirus

G. S. Fout{dagger} and E. H. Simon

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, U.S.A.

Two distinct antiviral activities can be detected in L cells treated with low levels of interferon and infected with a one-step interferon-sensitive mutant of mengovirus (is-1). The first antiviral activity (AVA-1) primarily delayed virus RNA and protein synthesis and thereby lengthened the virus replication cycle. It did not prevent cell death. The second antiviral activity (AVA-2) allowed the virus-induced inhibition of host macromolecular synthesis but inhibited all other virus functions. By 9 to 12 h post-infection host synthesis resumed and most cells survived. The data suggest that some step in the virus replication cycle activates AVA-2 leading to the destruction of the virus genome 6 to 12 h after infection. In unprotected cells the yields of parental virus (is+) and is-1 were similar. No qualitative or quantitative differences in virus products were observed by several techniques. The is-1 virus seems to have lost a wild-type function which normally blocks the action of AVA-2.

Keywords: mengovirus, interferon-sensitive, antiviral activity

{dagger} Present address: Biophysics Laboratory, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.

Received 20 October 1982; accepted 10 February 1983.




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Copyright © 1983 by the Society for General Microbiology.