HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gray, M. A. Articles by Pasternak, C. A. Search for Related Content PubMed PubMed Citation Articles by Gray, M. A. Articles by Pasternak, C. A. Agricola Articles by Gray, M. A. Articles by Pasternak, C. A.

Effect of Vesicular Stomatitis Virus and Semliki Forest Virus on Uptake of Nutrients and Intracellular Cation Concentration

K. J. Micklem^1,

¹ Department of Biochemistry, St George's Hospital Medical School, London SW17 0RE
and² Animal Virus Research Institute, Pirbright, Woking, Surrey GU24 0NF, U.K.

BHK-21 cells showed an increased ability to concentrate 2-deoxy-D-glucose (dGlc) 2 to 3 h after infection with vesicular stomatitis virus (VSV) or Semliki Forest virus (SFV), which began to be released at 2 and 3 h post-infection respectively; uptake of other nutrients was not affected in this way. Intracellular Na⁺ was either unchanged (VSV-infected cells) or increased (SFV-infected cells); K⁺ content was unchanged. These results do not support the current hypothesis that a non-specific increase in membrane permeability occurs in cells infected with rhabdoviruses or togaviruses.

Keywords: VSV, SFV, membrane permeability

Present address: Department of Biochemistry, University of Oxford, Oxford OX1 2JD, U.K.

Received 13 December 1982; accepted 8 February 1983.