HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ghendon, Y. Z. Articles by Polezhaev, F. I. Search for Related Content PubMed PubMed Citation Articles by Ghendon, Y. Z. Articles by Polezhaev, F. I. Agricola Articles by Ghendon, Y. Z. Articles by Polezhaev, F. I.

Analysis of Genome Composition and Reactogenicity of Recombinants of Cold-adapted and Virulent Virus Strains

¹ Moscow Research Institute for Viral Preparations, 15, 1st Dubrovskaya Str., Moscow 109088, U.S.S.R.
and² Institute of Experimental Medicine, Leningrad, U.S.S.R.

Temperature-sensitive (ts) mutations occurring in three genes 1, 2 and 7, and 1, 5 and 7 were found in two cold-adapted (ts) attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.

Received 2 May 1980; accepted 27 October 1980.

This article has been cited by other articles:

				T. M. Tsfasman, S. G. Markushin, I. I. Akopova, and Y. Z. Ghendon Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains J. Gen. Virol., October 1, 2007; 88(10): 2724 - 2729. [Abstract] [Full Text] [PDF]