HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Walder, R. Articles by Bradish, C. J. Search for Related Content PubMed PubMed Citation Articles by Walder, R. Articles by Bradish, C. J. Agricola Articles by Walder, R. Articles by Bradish, C. J.

Multi-factorial Specification of Virus-Host Interactions: Studies with Strains of Venezuelan Equine Encephalomyelitis Virus in Mice

C. J. Bradish

^* Instituto Venezolano de Investigaciones Cientificas, Centro de Microbiologia and Biologia Celular, Laboratorio de Virus Animales, Apartado 1827, Caracas, Venezuela
Microbiological Research Establishment, Porton Down, Salisbury, U.K.

Mice of different ages were infected i.p. or i.c. by 23 different strains of VEE virus. The course of the virus host interaction was specified in terms of the efficiency of infection, the outcome of infection as lethality or protection and the survival time. These separately quantifiable features all showed several host-maturation events that combine to provide a multifactorial specification of virus-strains and host-responses. This base-line for correlations with the responses of principal hosts (equidae and man) may be expanded to test correlations with the antigenic or in vitro characteristics of virus-strains.

Received 11 October 1978; accepted 17 January 1979.