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Cross-Neutralization Study of Seven California Group (Bunyaviridae) Strains in Homoiothermous (PS) and Poikilothermous (XTC-2) Vertebrate Cells

Arbovirus Unit, Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, London WC1

Antigenic relationships among seven California group strains were studied by a plaque-reduction neutralization test (PRNT). Cross-reactions occurred in most cases but three subgroups were noted: (1) the major serogroup contained the viruses of California encephalitis, LaCrosse, Snowshoe Hare and rahya (including the Lumbo strain) whereas (2) Jamestown Canyon and (3) Trivittatus viruses were distinct. There was no significant difference between the PRNT results in mammalian (PS) cells incubated at 37 °C and amphibian (XTC-2) cells incubated at 28 °C. Trivittatus virus failed to produce plaques in XTC-2 cells.

^* Present address: Institute of Parasitology, Czechoslovak Academy of Sciences, 166 32 Prague, Czechoslovakia.

Received 22 June 1978; accepted 24 August 1978.