HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bell, D. Search for Related Content PubMed PubMed Citation Articles by Bell, D. Agricola Articles by Bell, D.

The Effect of Canavanine on Herpes Simplex Virus Replication

Institute of Virology, University of Glasgow, Glasgow, G11 5JR, Scotland

The arginine analogue canavanine strongly inhibited the replication of herpes simplex virus in BSC-1 cells. Virus absorption and entry of the virus DNA into the cell nucleus were unaffected. However, changes qualitatively similar to those produced by arginine deprivation did occur. There was little inhibition of protein synthesis but the transport of proteins from cytoplasm to nucleus was substantially reduced. Virus DNA synthesis which was extremely sensitive early in the growth cycle was little affected at late times although virus maturation was still prevented. Possible modes of action of the drug are discussed.

^* Present address: Department of Biochemistry, University of Glasgow, Giasgow G12 8QQ.

Received 13 August 1973; accepted 24 October 1973.