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Non-specific Serum Inhibitors of Activity of Haemagglutinins of Rabies and Vesicular Stomatitis Viruses

Department of Virology, Department of Medical Microbiology and Department of Medical Chemistry, University of Turku, Turku, Finland

A pooled normal human serum at up to about 1:4000 dilution inhibited haemagglutination by rabies and vesicular stomatitis viruses. Serum lipoproteins were found to carry almost all of the inhibitory activity, which specifically resided in the phospholipids of these lipoproteins. Commercially available phospholipids and cholesterol were also effective inhibitors of virus haemagglutination. The inhibitory activity of the mixture of cholesterol and lecithin tested against the haemagglutinins of vesicular stomatitis virus, rabies virus and an arbovirus (LaCrosse strain of California arbovirus group) were 2 to 8 times higher than that for the lipids alone, whereas the inhibitory activity of the mixture of cholesterol and palmitic acid was not higher than that of cholesterol alone. Adsorption with kaolin, as well as fractionation by DEAE-cellulose chromatography, effectively separated the non-specific inhibitors from specific antibodies contained in burro anti-rabies virus serum.

Received 12 April 1973; accepted 22 October 1973.

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